Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial.
Identifieur interne : 000656 ( Main/Exploration ); précédent : 000655; suivant : 000657Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial.
Auteurs : Ruben A. Mesa [États-Unis] ; Alessandro M. Vannucchi [Italie] ; Adam Mead [Royaume-Uni] ; Miklos Egyed [Hongrie] ; Anita Szoke [Hongrie] ; Aleksandr Suvorov [Russie] ; Janos Jakucs [Hongrie] ; Andrew Perkins [Australie] ; Ritam Prasad [Australie] ; Jiri Mayer [République tchèque] ; Judit Demeter [Hongrie] ; Peter Ganly [Nouvelle-Zélande] ; Jack W. Singer [États-Unis] ; Huafeng Zhou [États-Unis] ; James P. Dean [États-Unis] ; Peter A. Te Boekhorst [Pays-Bas] ; Jyoti Nangalia [Royaume-Uni] ; Jean-Jacques Kiladjian [France] ; Claire N. Harrison [Royaume-Uni]Source :
- The Lancet. Haematology [ 2352-3026 ] ; 2017.
Abstract
Available therapies for myelofibrosis can exacerbate cytopenias and are not indicated for patients with severe thrombocytopenia. Pacritinib, which inhibits both JAK2 and FLT3, induced spleen responses with limited myelosuppression in phase 1/2 trials. We aimed to assess the efficacy and safety of pacritinib versus best available therapy in patients with myelofibrosis irrespective of baseline cytopenias.
DOI: 10.1016/S2352-3026(17)30027-3
PubMed: 28336242
Affiliations:
- Australie, France, Hongrie, Italie, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, Russie, République tchèque, États-Unis
- Angleterre, Arizona, Grand Londres, Hollande-Méridionale, Hongrie centrale, Moravie, Oxfordshire, Washington (État), Île-de-France
- Brno, Budapest, Londres, Oxford, Paris, Rotterdam
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Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Békés Megyei Pándy Kálmán Kórház, Gyula</wicri:regionArea><wicri:noRegion>Gyula</wicri:noRegion></affiliation></author><author><name sortKey="Perkins, Andrew" sort="Perkins, Andrew" uniqKey="Perkins A" first="Andrew" last="Perkins">Andrew Perkins</name><affiliation wicri:level="1"><nlm:affiliation>ICON Cancer Care, South Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ICON Cancer Care, South Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Prasad, Ritam" sort="Prasad, Ritam" uniqKey="Prasad R" first="Ritam" last="Prasad">Ritam Prasad</name><affiliation wicri:level="1"><nlm:affiliation>Royal Hobart Hospital, Hobart, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Hobart Hospital, Hobart</wicri:regionArea><wicri:noRegion>Hobart</wicri:noRegion></affiliation></author><author><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, University Hospital Brno, Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Internal Medicine, University Hospital Brno, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Demeter, Judit" sort="Demeter, Judit" uniqKey="Demeter J" first="Judit" last="Demeter">Judit Demeter</name><affiliation wicri:level="3"><nlm:affiliation>First Department of Internal Medicine, Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>First Department of Internal Medicine, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Ganly, Peter" sort="Ganly, Peter" uniqKey="Ganly P" first="Peter" last="Ganly">Peter Ganly</name><affiliation wicri:level="1"><nlm:affiliation>Department of Haematology, Christchurch Hospital, Christchurch, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Haematology, Christchurch Hospital, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Singer, Jack W" sort="Singer, Jack W" uniqKey="Singer J" first="Jack W" last="Singer">Jack W. Singer</name><affiliation wicri:level="2"><nlm:affiliation>CTI BioPharma Corp, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CTI BioPharma Corp, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Zhou, Huafeng" sort="Zhou, Huafeng" uniqKey="Zhou H" first="Huafeng" last="Zhou">Huafeng Zhou</name><affiliation wicri:level="2"><nlm:affiliation>CTI BioPharma Corp, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CTI BioPharma Corp, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Dean, James P" sort="Dean, James P" uniqKey="Dean J" first="James P" last="Dean">James P. 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Harrison</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28336242</idno><idno type="pmid">28336242</idno><idno type="doi">10.1016/S2352-3026(17)30027-3</idno><idno type="wicri:Area/PubMed/Corpus">000C32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C32</idno><idno type="wicri:Area/PubMed/Curation">000C29</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C29</idno><idno type="wicri:Area/PubMed/Checkpoint">000C29</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C29</idno><idno type="wicri:Area/Ncbi/Merge">004518</idno><idno type="wicri:Area/Ncbi/Curation">004518</idno><idno type="wicri:Area/Ncbi/Checkpoint">004518</idno><idno type="wicri:Area/Main/Merge">000651</idno><idno type="wicri:Area/Main/Curation">000656</idno><idno type="wicri:Area/Main/Exploration">000656</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial.</title><author><name sortKey="Mesa, Ruben A" sort="Mesa, Ruben A" uniqKey="Mesa R" first="Ruben A" last="Mesa">Ruben A. Mesa</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ, USA. Electronic address: mesa.ruben@mayo.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Vannucchi, Alessandro M" sort="Vannucchi, Alessandro M" uniqKey="Vannucchi A" first="Alessandro M" last="Vannucchi">Alessandro M. Vannucchi</name><affiliation wicri:level="1"><nlm:affiliation>Center of Research and Innovation of Myeloproliferative Neoplasms, Department of Experimental and Clinical Medicine, AOU Careggi and University of Florence, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Center of Research and Innovation of Myeloproliferative Neoplasms, Department of Experimental and Clinical Medicine, AOU Careggi and University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Mead, Adam" sort="Mead, Adam" uniqKey="Mead A" first="Adam" last="Mead">Adam Mead</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Haematology, NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Haematology, NIHR Biomedical Research Centre, Churchill Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Egyed, Miklos" sort="Egyed, Miklos" uniqKey="Egyed M" first="Miklos" last="Egyed">Miklos Egyed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Somogy County Kaposi Mor Hospital, Kaposvar, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Hematology, Somogy County Kaposi Mor Hospital, Kaposvar</wicri:regionArea><wicri:noRegion>Kaposvar</wicri:noRegion></affiliation></author><author><name sortKey="Szoke, Anita" sort="Szoke, Anita" uniqKey="Szoke A" first="Anita" last="Szoke">Anita Szoke</name><affiliation wicri:level="1"><nlm:affiliation>Second Department of Internal Medicine and Cardiology Center, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Second Department of Internal Medicine and Cardiology Center, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Suvorov, Aleksandr" sort="Suvorov, Aleksandr" uniqKey="Suvorov A" first="Aleksandr" last="Suvorov">Aleksandr Suvorov</name><affiliation wicri:level="1"><nlm:affiliation>First Republican Clinical Hospital of Udmurtia, Izhevsk, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>First Republican Clinical Hospital of Udmurtia, Izhevsk</wicri:regionArea><wicri:noRegion>Izhevsk</wicri:noRegion></affiliation></author><author><name sortKey="Jakucs, Janos" sort="Jakucs, Janos" uniqKey="Jakucs J" first="Janos" last="Jakucs">Janos Jakucs</name><affiliation wicri:level="1"><nlm:affiliation>Békés Megyei Pándy Kálmán Kórház, Gyula, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Békés Megyei Pándy Kálmán Kórház, Gyula</wicri:regionArea><wicri:noRegion>Gyula</wicri:noRegion></affiliation></author><author><name sortKey="Perkins, Andrew" sort="Perkins, Andrew" uniqKey="Perkins A" first="Andrew" last="Perkins">Andrew Perkins</name><affiliation wicri:level="1"><nlm:affiliation>ICON Cancer Care, South Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ICON Cancer Care, South Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Prasad, Ritam" sort="Prasad, Ritam" uniqKey="Prasad R" first="Ritam" last="Prasad">Ritam Prasad</name><affiliation wicri:level="1"><nlm:affiliation>Royal Hobart Hospital, Hobart, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Hobart Hospital, Hobart</wicri:regionArea><wicri:noRegion>Hobart</wicri:noRegion></affiliation></author><author><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, University Hospital Brno, Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Internal Medicine, University Hospital Brno, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Demeter, Judit" sort="Demeter, Judit" uniqKey="Demeter J" first="Judit" last="Demeter">Judit Demeter</name><affiliation wicri:level="3"><nlm:affiliation>First Department of Internal Medicine, Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>First Department of Internal Medicine, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Ganly, Peter" sort="Ganly, Peter" uniqKey="Ganly P" first="Peter" last="Ganly">Peter Ganly</name><affiliation wicri:level="1"><nlm:affiliation>Department of Haematology, Christchurch Hospital, Christchurch, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Haematology, Christchurch Hospital, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Singer, Jack W" sort="Singer, Jack W" uniqKey="Singer J" first="Jack W" last="Singer">Jack W. Singer</name><affiliation wicri:level="2"><nlm:affiliation>CTI BioPharma Corp, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CTI BioPharma Corp, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Zhou, Huafeng" sort="Zhou, Huafeng" uniqKey="Zhou H" first="Huafeng" last="Zhou">Huafeng Zhou</name><affiliation wicri:level="2"><nlm:affiliation>CTI BioPharma Corp, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CTI BioPharma Corp, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Dean, James P" sort="Dean, James P" uniqKey="Dean J" first="James P" last="Dean">James P. Dean</name><affiliation wicri:level="2"><nlm:affiliation>CTI BioPharma Corp, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CTI BioPharma Corp, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Te Boekhorst, Peter A" sort="Te Boekhorst, Peter A" uniqKey="Te Boekhorst P" first="Peter A" last="Te Boekhorst">Peter A. Te Boekhorst</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Nangalia, Jyoti" sort="Nangalia, Jyoti" uniqKey="Nangalia J" first="Jyoti" last="Nangalia">Jyoti Nangalia</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Instutite, Hinxton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Instutite, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation></author><author><name sortKey="Kiladjian, Jean Jacques" sort="Kiladjian, Jean Jacques" uniqKey="Kiladjian J" first="Jean-Jacques" last="Kiladjian">Jean-Jacques Kiladjian</name><affiliation wicri:level="3"><nlm:affiliation>Centre d'Investigations Cliniques, APHP, Hôpital Saint-Louis, INSERM CIC 1427, Paris, France; Paris Diderot University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Investigations Cliniques, APHP, Hôpital Saint-Louis, INSERM CIC 1427, Paris, France; Paris Diderot University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Harrison, Claire N" sort="Harrison, Claire N" uniqKey="Harrison C" first="Claire N" last="Harrison">Claire N. Harrison</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Haematology</title><idno type="eISSN">2352-3026</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Available therapies for myelofibrosis can exacerbate cytopenias and are not indicated for patients with severe thrombocytopenia. Pacritinib, which inhibits both JAK2 and FLT3, induced spleen responses with limited myelosuppression in phase 1/2 trials. We aimed to assess the efficacy and safety of pacritinib versus best available therapy in patients with myelofibrosis irrespective of baseline cytopenias.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Hongrie</li><li>Italie</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Russie</li><li>République tchèque</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Arizona</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Hongrie centrale</li><li>Moravie</li><li>Oxfordshire</li><li>Washington (État)</li><li>Île-de-France</li></region><settlement><li>Brno</li><li>Budapest</li><li>Londres</li><li>Oxford</li><li>Paris</li><li>Rotterdam</li></settlement></list><tree><country name="États-Unis"><region name="Arizona"><name sortKey="Mesa, Ruben A" sort="Mesa, Ruben A" uniqKey="Mesa R" first="Ruben A" last="Mesa">Ruben A. Mesa</name></region><name sortKey="Dean, James P" sort="Dean, James P" uniqKey="Dean J" first="James P" last="Dean">James P. Dean</name><name sortKey="Singer, Jack W" sort="Singer, Jack W" uniqKey="Singer J" first="Jack W" last="Singer">Jack W. Singer</name><name sortKey="Zhou, Huafeng" sort="Zhou, Huafeng" uniqKey="Zhou H" first="Huafeng" last="Zhou">Huafeng Zhou</name></country><country name="Italie"><noRegion><name sortKey="Vannucchi, Alessandro M" sort="Vannucchi, Alessandro M" uniqKey="Vannucchi A" first="Alessandro M" last="Vannucchi">Alessandro M. Vannucchi</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mead, Adam" sort="Mead, Adam" uniqKey="Mead A" first="Adam" last="Mead">Adam Mead</name></region><name sortKey="Harrison, Claire N" sort="Harrison, Claire N" uniqKey="Harrison C" first="Claire N" last="Harrison">Claire N. Harrison</name><name sortKey="Nangalia, Jyoti" sort="Nangalia, Jyoti" uniqKey="Nangalia J" first="Jyoti" last="Nangalia">Jyoti Nangalia</name></country><country name="Hongrie"><noRegion><name sortKey="Egyed, Miklos" sort="Egyed, Miklos" uniqKey="Egyed M" first="Miklos" last="Egyed">Miklos Egyed</name></noRegion><name sortKey="Demeter, Judit" sort="Demeter, Judit" uniqKey="Demeter J" first="Judit" last="Demeter">Judit Demeter</name><name sortKey="Jakucs, Janos" sort="Jakucs, Janos" uniqKey="Jakucs J" first="Janos" last="Jakucs">Janos Jakucs</name><name sortKey="Szoke, Anita" sort="Szoke, Anita" uniqKey="Szoke A" first="Anita" last="Szoke">Anita Szoke</name></country><country name="Russie"><noRegion><name sortKey="Suvorov, Aleksandr" sort="Suvorov, Aleksandr" uniqKey="Suvorov A" first="Aleksandr" last="Suvorov">Aleksandr Suvorov</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Perkins, Andrew" sort="Perkins, Andrew" uniqKey="Perkins A" first="Andrew" last="Perkins">Andrew Perkins</name></noRegion><name sortKey="Prasad, Ritam" sort="Prasad, Ritam" uniqKey="Prasad R" first="Ritam" last="Prasad">Ritam Prasad</name></country><country name="République tchèque"><region name="Moravie"><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name></region></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Ganly, Peter" sort="Ganly, Peter" uniqKey="Ganly P" first="Peter" last="Ganly">Peter Ganly</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Te Boekhorst, Peter A" sort="Te Boekhorst, Peter A" uniqKey="Te Boekhorst P" first="Peter A" last="Te Boekhorst">Peter A. Te Boekhorst</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Kiladjian, Jean Jacques" sort="Kiladjian, Jean Jacques" uniqKey="Kiladjian J" first="Jean-Jacques" last="Kiladjian">Jean-Jacques Kiladjian</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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